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KMID : 1007520150240010295
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Food Science and Biotechnology
2015 Volume.24 No. 1 p.295 ~ p.300
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Effects of Blue Mussel (ME) Water Extracts on Pentobarbital-induced Sleep and the Sleep Architecture in Mice
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Ta Quang-Van
Yoon Min-Seok
Yang Hye-Jin
Kim Ji-young
Cho Sueng-Mok
Kang Kyong-Hwa
Kim Young-Sang
Park Sun-Joo
Kim Se-Kwon
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Abstract
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Blue mussel (Mytilus edulis) is a popular shellfish that is used widely in the daily diet. It has antioxidant, antimicrobial, and anticoagulant properties. The hypnotic effects of blue mussel (ME) water extracts in a mouse model were investigated. Oral administration of ME water extracts produced a dose-dependent decrease in sleep latency and an increase in sleep duration in pentobarbitaltreated mice. At concentrations of 500 and 1,000 mg/kg, the extracts also increased the sleep onset rate (90 and 90%, respectively) and sleep duration (46.3±4.9 and 58.3±2.0 min, respectively) in sub-hypnotic dosage testing. Electroencephalograms (EEG) and electromyograms (EMG) showed that ME water extracts reduced sleep latency and induced non-rapid eye movement sleep (NREMS) while maintaining rapid eye movement sleep (REMS). ME water extracts did not affect the EEG power density. ME water extract-induced sleep is similar to physiological sleep in a mouse model.
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KEYWORD
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mussel, hypnotic, pentobarbital, electroencephalogram
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